TABLE II. Genes altered by both exogenous and endogenous oxidative stress.
A list of genes showing a significant difference of greater than 1.5-fold when we compared untreated WT mice with either WT mice treated with diquat or untreated Gpx1−/− and Sod1−/− mice. Duplicates (by gene name or unigene ID) were removed.
Gene Symbol | Gene Name | 1h DQ |
3h DQ |
6h DQ |
12h DQ |
Gpx1−/− | Sod1−/− |
---|---|---|---|---|---|---|---|
Igfbp1 | insulin-like growth factor binding protein 1 |
6.42 | 7.72 | 6.96 | 6.22 | 5.23 | |
Mt1b | metallothionein 1 | 2.88 | 5.87 | 7.52 | 8.29 | 4.52 | |
Atf3abc | activating transcription factor 3 | 2.10 | 3.40 | ||||
Pdk4b | pyruvate dehydrogenase kinase, isoenzyme 4 |
5.27 | 4.10 | 12.53 | 3.27 | ||
Apoa4 | apolipoprotein A-IV | 2.62 | 13.67 | 3.26 | |||
Tubb2 | Tubulin, beta 2 | 1.85 | 2.07 | 2.45 | 3.50 | 2.76 | 2.68 |
Copebb | Kruppel-like factor 6 (Klf6) | 2.02 | 2.04 | 1.57 | 2.58 | ||
Rsb30 | RAB30, member RAS oncogene family | 7.64 | 7.31 | 18.57 | 2.50 | ||
3110043O21Rik | RIKEN cDNA 3110043O21 gene | 2.10 | 3.27 | 2.30 | 3.74 | 2.41 | |
Mtap | methylthioadenosine phosphorylase | 2.87 | 3.87 | 4.66 | 2.27 | ||
Ddit4abc | DNA-damage-inducible transcript 4 | 5.04 | 5.65 | 8.43 | 6.20 | 2.27 | |
Orm2 | orosomucoid 2 | 2.04 | 3.80 | 2.20 | |||
Cdkn1aabc | cyclin-dependent kinase inhibitor 1A (P21) |
4.27 | 8.52 | 14.50 | 2.12 | ||
Hist 1h1c | Histone 1, H1c | 1.75 | 2.76 | 2.08 | |||
St5 | suppression of tumorigenicity 5 | 1.89 | 4.24 | 2.05 | |||
Gdf15ac | Growth differentiation factor 15 | 2.26 | 3.72 | 1.98 | 1.91 | ||
Ndrg1ab | N-myc downstream regulated gene 1 | 1.82 | 1.89 | ||||
Trp53inp1a | transformation related protein 53 inducible nuclear protein 1 |
1.94 | 2.67 | 2.29 | 1.77 | 1.83 | |
Arl4 | ADP-ribosylation factor-like 4 | 1.47 | 1.67 | 1.44 | 2.31 | 1.81 | |
Enc1 | ectodermal-neural cortex 1 | 1.56 | 2.32 | 1.66 | |||
5730438N18Rik | RIKEN cDNA 5730438N18 gene | 2.14 | 2.29 | 1.69 | 1.61 | ||
Ifrd1 | interferon-related developmental regulator 1 |
1.55 | 3.66 | 2.62 | 2.45 | 1.58 | |
Ube2g2 | ubiquitin-conjugating enzyme E2G 2 | 1.38 | 1.80 | 1.76 | 1.52 | ||
Stard4 | StAR-related lipid transfer (START) domain containing 4 |
−1.45 | −1.62 | −1.90 | −4.95 | −1.69 | |
3100002L24Rik | RIKEN cDNA 3100002L24 gene | −1.53 | −2.07 | −2.32 | −2.57 | −1.54 | |
Gpr146 | G protein-coupled receptor 146 | −1.48 | −1.32 | −1.50 | −1.68 | −1.72 | −1.68 |
D5Ertd593e | DNA segment, Chr 5, ERATO Doi 593, expressed |
−1.37 | −1.91 | −3.67 | −1.81 | ||
Fzd8 | frizzled homolog 8 (Drosophila) | −1.40 | −1.52 | −1.38 | −1.63 | ||
Aacs | acetoacetyl-CoA synthetase | −1.71 | −1.96 | −1.93 | −1.88 | −2.12 | |
2210418O10Rik | RIKEN cDNA 2210418O10 gene | −1.46 | −1.63 | −2.10 | −1.83 | ||
4933439C20Rik | RIKEN cDNA 2210418O10 gene | −1.74 | −2.17 | −3.19 | −1.59 | ||
Pcmtd2 | protein-L-isoaspartate (D-aspartate) Omethyltransferase domain containing 2 |
−1.82 | −2.23 | −4.52 | −1.69 | −1.76 | |
Pcmtd2 | protein-L-isoaspartate (D-aspartate) Omethyltransferase domain containing 2 |
−1.82 | −2.23 | −4.52 | −1.69 | −1.76 | |
Lect1 | leukocyte cell derived chemotaxin 1 | −1.30 | −1.52 | −2.14 | −2.64 | −2.57 | |
Hsd3b5 | hydroxysteroid dehydrogenase-5, delta<5>-3-beta |
−2.27 | −9.84 | −5.82 |