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. Author manuscript; available in PMC: 2009 Jun 12.
Published in final edited form as: Physiol Genomics. 2008 Apr 29;34(1):112–126. doi: 10.1152/physiolgenomics.00239.2007

TABLE II. Genes altered by both exogenous and endogenous oxidative stress.

A list of genes showing a significant difference of greater than 1.5-fold when we compared untreated WT mice with either WT mice treated with diquat or untreated Gpx1−/− and Sod1−/− mice. Duplicates (by gene name or unigene ID) were removed.

Gene Symbol Gene Name 1h
DQ
3h
DQ
6h
DQ
12h
DQ
Gpx1−/− Sod1−/−
Igfbp1 insulin-like growth factor binding
protein 1
6.42 7.72 6.96 6.22 5.23
Mt1b metallothionein 1 2.88 5.87 7.52 8.29 4.52
Atf3abc activating transcription factor 3 2.10 3.40
Pdk4b pyruvate dehydrogenase kinase,
isoenzyme 4
5.27 4.10 12.53 3.27
Apoa4 apolipoprotein A-IV 2.62 13.67 3.26
Tubb2 Tubulin, beta 2 1.85 2.07 2.45 3.50 2.76 2.68
Copebb Kruppel-like factor 6 (Klf6) 2.02 2.04 1.57 2.58
Rsb30 RAB30, member RAS oncogene family 7.64 7.31 18.57 2.50
3110043O21Rik RIKEN cDNA 3110043O21 gene 2.10 3.27 2.30 3.74 2.41
Mtap methylthioadenosine phosphorylase 2.87 3.87 4.66 2.27
Ddit4abc DNA-damage-inducible transcript 4 5.04 5.65 8.43 6.20 2.27
Orm2 orosomucoid 2 2.04 3.80 2.20
Cdkn1aabc cyclin-dependent kinase inhibitor 1A
(P21)
4.27 8.52 14.50 2.12
Hist 1h1c Histone 1, H1c 1.75 2.76 2.08
St5 suppression of tumorigenicity 5 1.89 4.24 2.05
Gdf15ac Growth differentiation factor 15 2.26 3.72 1.98 1.91
Ndrg1ab N-myc downstream regulated gene 1 1.82 1.89
Trp53inp1a transformation related protein 53
inducible nuclear protein 1
1.94 2.67 2.29 1.77 1.83
Arl4 ADP-ribosylation factor-like 4 1.47 1.67 1.44 2.31 1.81
Enc1 ectodermal-neural cortex 1 1.56 2.32 1.66
5730438N18Rik RIKEN cDNA 5730438N18 gene 2.14 2.29 1.69 1.61
Ifrd1 interferon-related developmental
regulator 1
1.55 3.66 2.62 2.45 1.58
Ube2g2 ubiquitin-conjugating enzyme E2G 2 1.38 1.80 1.76 1.52
Stard4 StAR-related lipid transfer (START)
domain containing 4
−1.45 −1.62 −1.90 −4.95 −1.69
3100002L24Rik RIKEN cDNA 3100002L24 gene −1.53 −2.07 −2.32 −2.57 −1.54
Gpr146 G protein-coupled receptor 146 −1.48 −1.32 −1.50 −1.68 −1.72 −1.68
D5Ertd593e DNA segment, Chr 5, ERATO Doi 593,
expressed
−1.37 −1.91 −3.67 −1.81
Fzd8 frizzled homolog 8 (Drosophila) −1.40 −1.52 −1.38 −1.63
Aacs acetoacetyl-CoA synthetase −1.71 −1.96 −1.93 −1.88 −2.12
2210418O10Rik RIKEN cDNA 2210418O10 gene −1.46 −1.63 −2.10 −1.83
4933439C20Rik RIKEN cDNA 2210418O10 gene −1.74 −2.17 −3.19 −1.59
Pcmtd2 protein-L-isoaspartate (D-aspartate) Omethyltransferase
domain containing
2
−1.82 −2.23 −4.52 −1.69 −1.76
Pcmtd2 protein-L-isoaspartate (D-aspartate) Omethyltransferase
domain containing
2
−1.82 −2.23 −4.52 −1.69 −1.76
Lect1 leukocyte cell derived chemotaxin 1 −1.30 −1.52 −2.14 −2.64 −2.57
Hsd3b5 hydroxysteroid dehydrogenase-5,
delta<5>-3-beta
−2.27 −9.84 −5.82
a

indicates that the gene is a p53 target based on references (44, 46);

b

indicates that the gene is altered in the same direction by paraquat in heart previously described by Edwards et al. (21);

b

indicates that the genes are altered in the same direction in human MCF7 and MRC9 cells in response to 100μM H2O2 as described by Desaint et al. (19).