TABLE 1.
Body and heart weight, glucose, and plasma lipid measurements in WT and LpLGPI mice
| WT | WT-myr | LpLGPI | LpLGPI-myr | |
|---|---|---|---|---|
| Body wt. (g) | 29.8 ± 2.1 | 27.7 ± 1.5 | 29.5 ± 1.5 | 30.6 ± 3.5 |
| Heart wt./body wt. (%) | 0.58 ± 0.02 | 0.53 ± 0.06 | 0.64 ± 0.02a | 0.51 ± 0.02a,b |
| Glucose (mg/dl) | 108 ± 3.9 | 103 ± 6.0 | 102 ± 7.7 | 104 ± 6.4 |
| TG (mg/dl) | 70.5 ± 12.7 | 63.9 ± 4.8 | 78.0 ± 9.5 | 73.5 ± 2.4 |
| Cholesterol (mg/dl) | 69.1 ± 1.75 | 74.5 ± 3.4 | 64.4 ± 4.7 | 74.1 ± 5.5 |
| FFA (mM) | 0.61 ± 0.12 | 0.44 ± 0.13 | 0.51 ± 0.08 | 0.43 ± 0.05 |
| SM (μg/ml) | 24.9 ± 2.3 | 12.1 ± 1.6a | 21.1 ± 5.0 | 9.1 ± 2.0a,b |
LpLGPI, glycosylphosphatidylinositol (GPI)-anchored human lipoprotein lipase; SM, sphingomyelin; myr, myriocin; TG, triglyceride; WT, wild type. Results are given as mean ± SEM, n = 8–10.
a
P < 0.05 (vs. WT).
b
P < 0.05 (vs. LpLGPI).