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. Author manuscript; available in PMC: 2008 Oct 1.

Published in final edited form as: Nat Immunol. 2008 Mar 9;9(4):405–414. doi: 10.1038/ni1575

Effects of elevated miR-17−92 expression levels on peripheral lymphocytes. (a) Lymphocyte subset numbers in the spleens of TG/TG and control mice. Each dot represents one mouse. (b) Flow cytometric analysis of phenotype of splenic CD4⁺ T and B cells in TG/TG and control mice of indicated ages. MZB, marginal zone B cells; GCB, germinal center B cells. Control mice include two hCD2-iCre mice analyzed at 7 weeks and three hCD2-iCre mice analyzed at 12 weeks. (c) Cell cycle analysis of MACS-purified peripheral CD4⁺ T cells from 20−45 week old mice. Percentage of cells in S-G2-M phases is graphed. Each dot represents one mouse. Bars indicate the mean values. (d) Flow cytometric analysis of phenotype of splenic B cells in TG/TG and control mice of indicated ages.

Effects of elevated miR-17−92 expression levels on peripheral lymphocytes. (a) Lymphocyte subset numbers in the spleens of TG/TG and control mice. Each dot represents one mouse. (b) Flow cytometric analysis of phenotype of splenic CD4⁺ T and B cells in TG/TG and control mice of indicated ages. MZB, marginal zone B cells; GCB, germinal center B cells. Control mice include two hCD2-iCre mice analyzed at 7 weeks and three hCD2-iCre mice analyzed at 12 weeks. (c) Cell cycle analysis of MACS-purified peripheral CD4⁺ T cells from 20−45 week old mice. Percentage of cells in S-G2-M phases is graphed. Each dot represents one mouse. Bars indicate the mean values. (d) Flow cytometric analysis of phenotype of splenic B cells in TG/TG and control mice of indicated ages.