Fig. 4.
Preservation of postsynaptic LTP mechanisms in PKA RIβ− mice. A, Direct postsynaptic depolarization of supragranular pyramidal cells (from −70 to 0 mV) induces LTP in mutant visual cortex when paired with synaptic stimulation (100 pulses at 1 Hz to layer IV). B, Robust LTP is similarly induced by pairing at Schaeffer collateral synapses studied as a control within the same slice. Nine cells from each region were recorded in slices from a total of seven mice. Sample traces 5 min before and 20 min after pairing are shown above each graph. Calibration: 100 pA, 20 msec.