Table 2.
Frequencies (%) of Conformational Changes at End Plates in Patients and Control Subjects
| Conformational Changes | Patients | Control Subjects |
|---|---|---|
| Degenerating junctional foldsa | 33 | 4 |
| Partially occupied postsynaptic region | 19 | 0 |
| Denuded postsynaptic region | 18 | 9 |
| Absent or highly simplified junctional foldsb | 16 | 9 |
| Degenerating subsynaptic organelles | 10 | 0 |
| Schwann cell encasement of nerve terminals | 9 | 0 |
| Degenerating nerve terminals | 3 | 0 |
A total of 613 Dok-7 and 162 control end-plate (EP) regions were analyzed. An EP region is defined as a nerve terminal and the associated postsynaptic region. More than one region can occur at an EP, and more than one conformational change can occur at an EP region.
a
Degeneration of junctional folds also simplifies the postsynaptic region.
b
Exclusive of postsynaptic regions with degenerating junctional folds.