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. 2008 Sep 16;99(8):1197–1203. doi: 10.1038/sj.bjc.6604636

Figure 3.

Figure 3

Function of the PI3K/AKT/mTOR signalling in cancer. Mammalian target of rapamycin (mTOR) may be activated in cancer cells and endothelial cells and may participate in cancer cell proliferation and tumour angiogenesis. Rapalogues that block downstream activation of this pathway may induce direct antiproliferative effects in cancer cells and may eventually inhibit tumour angiogenesis.