Table 6.
VH4-VH2 Repertoire Bias, MRI Lesion Load, Oligoclonal Banding and Conversion to Definite MS
| Subject | High Risk MRIA | Oligoclonal Bands | VH4 Bias in CD138 Plasma Cells | VH2 Bias in CD138 Plasma Cells | VH4 Bias in CD19 B Cells | VH2 Bias in CD19 B Cells | MS Risk Based on VH4-VH2 Bias | Definite MSB | Time to Diagnosis |
|---|---|---|---|---|---|---|---|---|---|
| ON03-3 | + | + | − | + | − | − | + | Clinical | 3 mo |
| ON03-5 | − | + | + | + | + | − | + | Clinical | 2 mo |
| ON04-7 | − | + | + | + | − | + | + | Clinical | 5 mo |
| ON04-8 | + | + | + | − | N.A.C | N.A. | + | Clinical | 5 mo |
| ON05-2 | − | + | + | − | + | − | + | Clinical | 3 mo |
| CIS03-1 | + | + | + | − | + | − | + | MRI | 3 mo |
| CIS04-3 | + | + | + | − | N.A. | N.A. | + | Clinical | 6 mo |
|
| |||||||||
| ON03-1 | + | + | − | − | − | − | − | − | − |
| ON03-4 | − | − | N.A. | N.A. | − | − | − | − | − |
| ON04-10 | + | − | N.A. | N.A. | − | − | − | − | − |
A
High risk MRI is defined as 2 or more T2-weighted lesions white matter lesions on brain imaging
B
MS was diagnosed by either a new clinical event (Clinical) or a new MRI lesion (MRI). MRI diagnosis was made by the International Criteria (Polman et al., 2005).
C
N.A. - Not amplified
Abbreviations: mo, months