Table 3.
Prevalence and mean severity of histopathological alterations in lungs of mice inhaling SWCNT
| Postexposure Duration/Histopathological Changes |
1 Day |
7 Days
|
28 Days
|
|||
|---|---|---|---|---|---|---|
| Control* | SWCNT* | Control* | SWCNT* | Control* | SWCNT* | |
| Inflammation | 0/5 (0±0) | 5/5 (5.1±0.1) | 0/5 (0±0) | 5/5 (5.0±0) | 0/5 (0±0) | 5/5 (5.0±0) |
| Anuclear macrophages | 0/5 (0±0) | 0/5 (0±0) | 0/5 (0±0) | 4/5 (0.8±0.2) | 0/5 (0±0) | 5/5 (1.0±0) |
| Bronchiolar epithelial changes† | 0/5 (0±0) | 5/5 (4.3±0.7) | 0/5 (0±0) | 5/5 (4.5±0.3) | 0/5 (0±0) | 4/5 (3.1±0.9) |
*
Prevalence (mean severity ± SE);
†
includes changes classified as hypertrophy with and without hyperplasia or peribronchiolar bronchiolization.