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The majority of the individuals tested responded to both the HLA class I- and class II-restricted epitope sets. (A) PBMCs from 20 individuals were tested for the recognition of pools of the set of class I-restricted (A) and class II-restricted (B) epitopes in IFN-γ ELISPOT assays. The average SI (specific response/nonspecific response) from three independent experiments is plotted for each donor. Gray bars, significantly positive responses; open bars, negative responses.
