Figure 4 (A) FISH analysis using the RP11‐355B11 BAC clone (at 2p15) marking the most centromeric margin of the 2p15‐16.1 deletion: (i) subject 2's mother, (ii) subject's 2 father, (iii) subject 2, and (iv) subject 1. Arrow indicates the normal chromosome 2 and the arrowhead indicates the deleted chromosome 2. (B) FISH analysis of RP11‐81L7 (at 2p16.1) marking the most telomeric clone from the common 2p15‐16.1 deletion region (4.5 Mb). (i) Subject 1's mother, (ii) subject 1's father; (iii) subject 1, and (iv) subject 2. Arrow indicates the normal chromosome 2 and the arrowhead indicates the deleted chromosome 2.