. Author manuscript; available in PMC: 2009 Dec 3.

Published in final edited form as: Eur J Pharmacol. 2008 Oct 1;599(1-3):91–95. doi: 10.1016/j.ejphar.2008.09.038

Table 1.

Effects of locally administered mecamylamine (10 μg) and α-conotoxin AuIB (25 pmol) on rates (mean responses per hour ± S.E.M.; Ns= 6−8) of methamphetamine self-administration and responding for sucrose

Reinforcer	Site^a	Treatment
		vehicle	mecamylamine	α-conotoxin uIB
methamphetamine	MHb	21.7±1.5	18.0±0.6^b	16.8±0.8^b
sucrose	MHb	23.9±2.4	23.0±2.5	23.6±2.7
methamphetamine	IPN	20.8±1.7	15.2±1.1^b	13.3±1.4^b
sucrose	IPN	23.1±0.9	25.3±2.3	22.8±1.5
methamphetamine	BLA	23.7±1.4	19.3±1.6^b	16.4±1.5^b
sucrose	BLA	25.1±2.6	18.0±2.8^b	15.8±2.2^b
methamphetamine	DLT	23.5±2.1	22.8±1.8	22.3±2.2
sucrose	DLT	24.8±1.6	19.7±2.2^b	19.1±2.4^b
methamphetamine	VTA	21.7±1.8	20.8±1.6	21.8±2.1
sucrose	VTA	24.8±2.3	25.5±2.9	27.1±3.2

MHB= medial habenula; IPN= interpeduncular nucleus; BLA= basolateral amygdala; DLT= dorsolateral tegmentum; VTA= ventral tegmental area

significantly different from baseline, p<0.05−0.02, paired t-test