Figure 9.
Endotoxin/LPS can induce oxidation of plasma Cys/CySS redox state by three mechanisms. Endotoxin-induced production of reactive oxygen species (1) is an early event that can contribute to the oxidation of Cys to CySS (2). Increased transport of Cys can further potentiate the early decrease in Cys levels. CySS transport is also induced by endotoxin-mediated effects. In the present study we see that reduced food intake (3) contributes to LPS-induced decrease in Cys, and concominant oxidation of plasma Cys/CySS redox state at later time points.