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. 2008 Nov 28;9:104. doi: 10.1186/1471-2350-9-104

Table 1.

Distribution of C677T genotype frequencies in the 20th century.

Frequencies by date of birth
C677T-MTHFR
Genotype-Allele 		1900–1925
(n = 206) 		1926–1950
(n = 320) 		1951–1975
(n = 408) 		1976–2000
(n = 371)
% n % n % n % n
CC 0.393 81 0.394 126 0.37 151 0.299* 111
CT 0.495 102 0.488 156 0.49 200 0.461 171
TT 0.112 23 0.119 38 0.14 57 0.24** 89
C allele 0.641 264 0.638 408 0.615 502 0.53** 393
T allele 0.359 148 0.363 232 0.385 314 0.47** 349

Note: *p < 0.05; **p < 0.01 (significance values in the last quarter of the century are relative to any other quarter of the century)