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. 2008 Dec 15;119(1):47–60. doi: 10.1172/JCI32310

Figure 3. Impaired allergic skin inflammation and systemic response to e.

Figure 3

. sensitization in Il21r–/– mice. (A) H&E staining of sections from saline- (SAL) and OVA-sensitized skin. Higher magnification of the boxed regions showed the presence of multiple eosinophils (arrowheads) in OVA-sensitized skin of WT mice, but not Il21r–/– mice. Original magnification, ×200; ×400 (higher-magnification panels). (B) Cell counts for skin-infiltrating CD4+ T cells and eosinophils. HPF, high-power field. (C and D) Quantitative RT-PCR analysis of mRNA levels of CCL17/TARC and CCL11/eotaxin-1 (C) and of IL-4, IL-13, and IFN-γ (D), expressed as fold induction compared with saline-sensitized skin sites. Values are mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001. n = 7 per group.