Figure 5. Il21r–/– DCs function normally in vitro, in contrast to impaired accumulation of adoptively transferred OVA-TCR transgenic WT T cells in DLNs of Il21r–/– mice.
(A) Proliferation and cytokine secretion of DO11.10 WT CD4+ T cells in response to OVA peptide presented by DCs from peripheral LNs of WT and Il21r–/– mice. (B and C) Analysis of CD4+KJ1.26+ cells in the DLNs of recipients of CD4+ OVA-TCR transgenic WT cells. Shown are representative FACS plots (B) and pooled results of 3 experiments (C). Percentages within plots denote percent cells within the boxed regions. *P < 0.05; **P < 0.01; ***P < 0.001.