Table 4.
Frequency and type of grade 3 or greater toxicity
| Type | Grade 3 (%) | Grade 4 (%) | All (%) |
|---|---|---|---|
| Hematologic (all types) | 3 (14) | 0 | 3 (14) |
| Neutropenia | 2 (10) | 0 | 2 (10) |
| Thrombocytopenia | 1 (4) | 0 | 1 (4) |
| Anemia | 0 | 0 | 0 |
| Neurologic | |||
| Reversible | 2a (10) | 0 | 2 (10) |
| Irreversible | 0 | 0 | 0 |
| Thrombosis | 4 (20) | 0 | 4 (20) |
| Wound infection | 3 (14) | 0 | 3 (14) |
| Transaminase elevation | 2 (10) | 0 | 2 (10) |
| Infection | 2 (10) | 0 | 2 (10) |
| Hyperglycemia | 1 (4) | 0 | 1 (4) |
| Avascular necrosis | 1 (4) | 0 | 1 (4) |
| Hyponatremia | 1 (4) | 0 | 1 (4) |
| Rash | 1 (4) | 0 | 1 (4) |
a
Both of these patients had grade 3 headache that resolved with corticosteroids.