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. 2009 Jan 23;5(1):e1000275. doi: 10.1371/journal.ppat.1000275

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Hamirally et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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At 96 hours p.i. (MOI = 1), cells were fixed and double-stained with a mouse monoclonal antibody against UL44, a replication compartment marker (red, left panels) and a goat antibody against lamin A/C (green, center panels). Signals from both antibodies were merged (right panels). (A) Wild-type HCMV strain AD169 (AD169) infected cells show characteristic deformation of the nuclei. The nuclei of cells infected with AD169 in the presence of 5 µM maribavir (AD169+MBV) (B) or in cells infected with UL97 deletion mutant virus RCΔ97 (Δ97) (C) retain the oval shape characteristic of mock-infected cells (mock) (D).