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. 2009 Jan 23;5(1):e1000275. doi: 10.1371/journal.ppat.1000275

Figure 6. Quantification of UL97-dependent nuclear lamina perturbations during HCMV infection.

Figure 6

(A) Occurrence of nuclear deformity in fibroblasts infected with HCMV strain AD169 (AD169), AD169 in the presence of maribavir (AD169+MBV), and independent isolates of UL97 deletion mutant RCΔ97 (RCΔ97.08) and (RCΔ97.19). Asterisk denotes Fisher's exact test p-value of <0.001 compared to AD169. Numbers above bars indicate numbers of cells scored. (B) Occurrence of gaps in the nuclear lamina in the same panel of cells scored above for nuclear deformity. Asterisk denotes Fisher exact test p-value of <0.001. These results show that UL97 is required for nuclear deformation and disruptions of lamina during HCMV infection.