Fig. 2.
Cell uptake studies. (A) Percentage total cell-associated fraction, cell-internalized fraction, and surface-bound fraction for the targeted nanoprobe in αvβ3-positive M21 cells. (B) Percentage cell-internalized fraction for the targeted nanoprobe in the absence and presence of the block and the nontargeted nanoprobe in αvβ3-positive M21 cells. All values are normalized to the protein content per well. Total cell-associated fraction represents the sum of cell-internalized fraction and surface-bound fraction. %ID/mg Protein refers to percentage injected or administered dose per milligram of protein.