Skip to main content
. Author manuscript; available in PMC: 2009 Apr 30.
Published in final edited form as: Nature. 2008 Sep 24;455(7217):1198–1204. doi: 10.1038/nature07319

Figure 3. Npas4 regulates GABAergic synapse development in organotypic hippocampal slices.

Figure 3

a, Representative mIPSCs recorded from CA1 pyramidal neurons in organotypic hippocampal slices biolistically co-transfected with GFP and either vector control, Npas4-RNAi or Npas4-minigene. b, Cumulative distributions of mIPSC inter-event intervals and amplitudes recorded from neurons transfected with vector control, Npas4-RNAi or Npas4-minigene. c, Mean ± s.e.m. of data from b. mIPSC inter-event intervals: 2986.3 ± 105.7, 3803.0 ± 136.9 and 1776.9 ± 75.1 ms; amplitudes: 31.5 ± 1.1, 25.7 ± 0.8 and 34.1 ± 1.3 pA; for vector control, Npas4-RNAi and Npas4-minigene, respectively. d, Cumulative distributions of mIPSC inter-event intervals and amplitudes recorded from Npas4flx/flx neurons co-transfected with GFP and either vector control or Cre recombinase. e, Mean ± s.e.m. of data from d. mIPSC inter-event intervals: 684.2 ± 31.2 and 917.4 ± 37.7 ms; amplitudes: 27.5 ± 0.7 and 27.9 ± 0.6 pA; for vector control and Cre, respectively. Total numbers of neurons analysed in each condition (n) are indicated in c and e. *P < 0.05; ***P < 0.001.