Table 1.
Characteristics of dieting group before and after weight loss
| Pre | Post | P Value (Pre → Post) | |
|---|---|---|---|
| Age, yr | 44.5 (28–54) | NA | |
| BMI, kg/m2 | 38 (29–54) | 32 (24–47) | <0.001 |
| %Fat | 37 (29–47) | 29 (19–41) | 0.002 |
| Fat mass, kg | 47 (25–79) | 32 (14–65) | <0.001 |
| Fat cell volume, μg TG/cell | 0.79 (0.55–1.14) | 0.55 (0.41–0.700) | <0.001 |
| Fat-free mass, kg | 77 (60–105) | 72 (57–94) | 0.012 |
| IAF, cm2 | 182 (122–295) | 90 (35–209) | <0.001 |
| SQF, cm2 | 436 (224–638) | 289 (108–499) | 0.002 |
| Leptin, ng/ml | 19 (7.6–44) | 12 (3.2–33) | 0.002 |
| Glucose, mg/dl | 78 (65–91) | 94 (84–108) | 0.004 |
| Insulin, μU/ml | 19 (4.4–30) | 10 (4.5–19) | 0.02 |
| SI, min−1·μU −1·ml−1 (× 10−4) | 1.2 (0.5–3.1) | 2.4 (1.0–3.9) | 0.002 |
| CPR, mg/day | 20 (11–26) | 18 (12–24) | 0.21 |
| MCR, l/day | 375 (231–472) | 355 (246–611) | 0.68 |
| CBG, mg/l | 21.5 (17–28) | 21.6 (17–26) | 0.91 |
| Free cortisol, μg/dl–day | 0.53 (0.37–0.66) | 0.52 (0.40–0.66) | 0.59 |
| 11β-HSD-1 mRNA, AU | 1.78 (0.65–2.29) | 0.99 (0.005–1.78) | 0.02 |
Values are means (range); n = 8 subjects. Pre, before weight loss; Post, after weight loss; BMI, body mass index; TG, triglyceride; IAF, intra-abdominal fat. SQF, abdominal subcutaneous fat; SI, insulin sensitivity; CPR, daily cortisol production rate; MCR, metabolic clearance rate of cortisol; CBG, cortisol binding globulin; 11β-HSD-1, 11β hydroxysteroid dehydrogenase-1; AU, arbitrary units; NA, not applicable.