Figure 1.
Pulmonary vasculature and plexiform lesions in macaques infected with simian immunodeficiency virus (SIV) or SHIV-nef (a chimeric viral construct containing the HIV nef gene in an SIV backbone). Paraffin-embedded sections from the lungs of macaques infected with SIVmac251-NENPRC1 (A), SHIV-nef1486D95-NENPRC7 (B), SHIV-nef1486D95-NENPRC8 (C), SIVmac239-CNPRC1 (D), SHIV-nefSF33A-CNPRC3 (E), or SHIV-nefSF33A-CNPRC4 (F) were stained with hematoxylin and eosin (H&E) and examined for vascular pathologies by two independent pathologists. Arrows indicate vessels with lymphocytic infiltration (SIV) and plexiform-like lesions (SHIV-nef). Scale bars: 100 μm.