Table 1.
The list of abundant phosphorylated proteins detected in the AD brain
| Protein names | GenBank™ accession number | # spectra of phosphopeptides | # phosphorylation sites |
|---|---|---|---|
|
Neurofilaments | |||
| neurofilament 3 (150kDa medium) | NP_001099011.1 | 591 | 18 |
| neurofilament, heavy polypeptide 200kDa | NP_066554.2 | 59 | 27 |
|
| |||
|
Microtubule-associated proteins | |||
| microtubule-associated protein 1B | NP_005900.2 | 194 | 53 |
| microtubule-associated protein 1A | NP_002364.5 | 46 | 18 |
| microtubule-associated protein 2 | NP_002365.3 | 27 | 5 |
| microtubule-associated protein tau | NP_005901.2 | 14 | 4 |
|
| |||
|
Other cytoskeletal proteins | |||
| adducin 1 (alpha) isoform b | NP_054909.2 | 125 | 4 |
| adducin 2 isoform c | NP_059517.1 | 29 | 12 |
| spectrin, beta, non-erythrocytic 1 | NP_003119.2 | 30 | 10 |
| ankyrin 2, isoform 1 | NP_001139.3 | 24 | 9 |
| ankyrin 2, isoform 2 | NP_066187.2 | 21 | 7 |
|
| |||
|
Synaptic components | |||
| syntaxin 1A | NP_004594.1 | 27 | 2 |
| syntaxin 1B | NP_443106.1 | 29 | 2 |
| amphiphysin II | NP_647597.1 | 43 | 3 |
| GAP-43 | NP_002036.1 | 23 | 9 |
| NAP-22/BASP1 | NP_006308.3 | 63 | 4 |
| A-kinase anchor protein 12 (AKAP12) | NP_005091.2 | 37 | 9 |
| myristoylated alanine-rich PKC substrate (MARCKS) | NP_002347.4 | 21 | 2 |
| neural cell adhesion molecule 1 isoform 2 (NCAM1) | NP_851996.2 | 16 | 2 |
|
| |||
|
Chaperones | |||
| Hsp90 | NP_031381.2 | 52 | 3 |