Fig. 2.
Statistical brain maps showing higher cerebral-to-cerebellar PiB DVR, a measure of fibrillar Aβ, in the 8 cognitively normal APOE ε4 heterozygotes (A) and the 8 cognitively normal homoyzogotes (B) compared with the 12 cognitively normal noncarriers, and associations between higher PiB DVR and APOE ε4 gene dose in the 28 cognitively normal subjects (C). Statistical maps are superimposed onto horizontal sections from a spatially standardized MRI image and are shown in relationship to their distance above or below a horizontal plane through the anterior and posterior commissures.