FIGURE 2.
Blood glucose kinetics before and during OGTT using the first order, one-compartment model. 9-h fasted male wild-type and Fxr–/– mice were subjected to an OGTT (11.3 mmol·kg–1, from which 30% was d-[U-13C]glucose) while they were infused with 4.4 μmol·kg–1·min–1 d-[6,6-2H2]glucose. A, blood glucose concentrations before and during the OGTT. B, calculated blood d-[U-13C]glucose concentrations from the fractional contribution of d-[U-13C]glucose with the estimated curve using SAAM II software. The values are averages ± S.E. (n = 5). *, p < 0.05; **, p < 0.01.