TABLE 1.
Particle height distribution of α-synuclein
α-Synuclein (70 μm) was incubated with or without syn-10H (15 μm) at 37 °C for 28 days. Data represent the height distribution analysis of the aggregates observed in the AFM images.
Time | 0-0.4 nm | 0.4-0.8 nm | 0.8-1 nm | 1-2 nm | 2-3 nm | 3-4 nm | > 4 nm | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
α-Synuclein alone | ||||||||||||||
0 h | 0.3 | 41.3 | 40.7 | 17.7 | 0.1 | 0.0 | 0.0 | |||||||
4 days | 3.9 | 70.0 | 19.6 | 5.4 | 0.8 | 0.3 | 0.1 | |||||||
7 days | 0.0 | 39.2 | 48.7 | 9.3 | 1.1 | 0.5 | 1.2 | |||||||
10 days | 0.1 | 0.8 | 4.2 | 65.5 | 11.5 | 7.5 | 10.4 | |||||||
12 days | 0.0 | 0.0 | 0.0 | 0.9 | 15.4 | 21.8 | 61.9 | |||||||
15 days | 0.0 | 0.0 | 0.0 | 1.4 | 26.1 | 20.3 | 52.2 | |||||||
20 days | 0.0 | 0.0 | 0.0 | 1.8 | 14.3 | 14.3 | 68.5 | |||||||
22 days | 0.0 | 0.0 | 0.1 | 17.9 | 54.6 | 5.0 | 22.4 | |||||||
28 days | 0.0 | 0.4 | 0.9 | 54.7 | 17.8 | 4.5 | 21.7 | |||||||
α-Synuclein + syn-10H scFv | ||||||||||||||
0 h | 22.2 | 74.6 | 2.2 | 0.7 | 0.2 | 0.1 | 0.0 | |||||||
4 days | 7.4 | 80.0 | 5.3 | 3.5 | 1.4 | 0.8 | 1.6 | |||||||
7 days | 0.5 | 26.2 | 35.4 | 37.7 | 0.2 | 0.0 | 0.0 | |||||||
10 days | 6.9 | 76.0 | 13.7 | 3.4 | 0.1 | 0.0 | 0.0 | |||||||
12 days | 0.1 | 18.9 | 41.7 | 37.1 | 1.2 | 0.4 | 0.6 | |||||||
15 days | 0.1 | 1.6 | 5.1 | 76.7 | 5.8 | 2.2 | 8.6 | |||||||
20 days | 0.0 | 0.9 | 5.7 | 71.4 | 8.7 | 5.4 | 7.8 | |||||||
22 days | 0.0 | 0.0 | 0.1 | 8.8 | 31.0 | 14.2 | 45.9 | |||||||
28 days | 0.0 | 0.0 | 0.0 | 2.7 | 13.6 | 20.0 | 63.7 |