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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Prog Biophys Mol Biol. 2008 Jun 20;98(1):85–106. doi: 10.1016/j.pbiomolbio.2008.05.007

Fig. 4. Mechanism of axin-dependent activation of HIPK2 kinase activity.

Fig. 4

HIPK2 is held in an inactive state by interactions between its kinase and axin-binding domains (KD and AD, respectively). Upon binding axin, inhibition is relieved and the KD is able to phosphorylate both the HIPK2-bound p53 molecule and the one bound to axin. Binding sites of HIPK2 and p53 on axin are depicted approximately to scale (see Fig. 3). Based on Fig. 8 of Rui et al. (Rui et al., 2004).