Fig. 2.
HDL Remodelling. Influence of plasma factors on the subpopulation distribution of HDL. LCAT generates cholesteryl esters and remodels discoidal HDL into spherical HDL (i); cholesteryl ester transfer protein (CETP) transfers cholesteryl esters and triglycerides between HDL, LDL, and VLDL; remodels HDL into small particles; and generates lipid-free/lipid-poor apoA-I (ii); phospholipid transfer protein (PLTP) transfers phospholipids between HDL and VLDL and between individual HDL particles; remodels HDL into large and small particles; and generates lipid-free/lipid-poor apoA-I (iii); endothelial lipase (EL) hydrolyses phospholipids and remodels HDL into small particles(iv); and hepatic lipase (HL) hydrolyses phospholipids and triglycerides, remodels HDL into small particles, and generates lipid-free/lipid-poor apoA-I (v).