Fig. 2.
Disruption of the Oxtr in mouse forebrain by Camk2a-driven Cre recombinase expression. Oxtr levels were examined by receptor binding in coronal sections from adult WT (A B, C), OxtrFB/FB (D, E, F), and Oxtr−/− (G, H, I) mice. Most areas in the forebrain of OxtrFB/FB mice show decreased levels of binding, with the notable exception of the medial amygdala (MA). Oxtr−/− mice show only background levels. Exposure was for 3 weeks to X-ray film (C). Abbreviations: Am, amygdala; AON, anterior olfactory nucleus; CP, caudate-putamen; Ctx, cerebral cortex; Hi, hippocampal formation; LS, lateral septum; MA, medial amygdala; OB, olfactory bulb; PC, piriform cortex; VP, ventral pallidum. Scale bar equals 0.5 cm. From (Lee et al., 2008).