Table 2.
In vivo models of metastatic mammary cancer
| Cell line | Genetic background | Spontaneous metastasis | Experimental metastasis | Oncogene(s) | TGFβ signaling |
|---|---|---|---|---|---|
| R3T | 129S1 mice | LNN, Lungs | Bone | PyVmT, H-rasmt | Normal |
| 4T1 | Balb/C mice | Lungs | Bone (lytic), Lungs | Unknown | Smad4 null |
| EMT6 | Balb/C mice | NT | Lungs | Unknown | NT |
| MMTV/PyVmT | FVB | Lungs | NT | PyVmT | NT |
| MDA-MB-231 | Human | No | Bone (lytic) | Unknown | TβR-II mutant |
| MDA-MB-435 | Human | LNN, Lung | NT | Unknown | Normal |
| MCF10ACA1a | Human | Lungs | Lungs | H-rasmt | NT |
| T47D | Human | No | LNN, Bone (blastic) | Unknown | TβR-II null |
| ZR75-1 | Human | No | Bone (blastic) | Unknown | NT |
| MCF7 | Human | No | Bone (blastic) | Unknown | NT |
| MX-1 | Human | NT | NT | Unknown | NT |
LNN, Lymph nodes; NT, Not tested; PyVmT, Polyoma middle T antigen