Table 1.
Poly(I: C) induces up regulation of gene expression of cytokines, chemokines, signaling molecules and TLRs in the lungs of mice.
| Cytokines/Chemokines | Fold Increase |
| CXCL10 | 357.38 |
| TNFα | 78.45 |
| CCL2 | 76.62 |
| CCL3 | 30.49 |
| CCL7 | 48.38 |
| TLRs | |
| TLR9 | 55.78 |
| TLR7 | 10.86 |
| TLR3 | 5.41 |
| TLR2 | 6.96 |
| Transcription Factors | |
| IRF7 | 22.92 |
| ISGF3G | 4.45 |
| Enzymes | |
| OAS2 | 10.76 |
| PKR | 9.32 |
Mice were administered PBS or 100 μg poly(I:C) I.N. every 24 h for three days. 24 h following the last poly(I:C) administration, lungs were lavaged, excised and frozen. RNA was isolated from the tissue and real-Time PCR was then performed. Data are expressed as fold change in mRNA expression over PBS-treated animals and represent pooled cDNA from 6 – 8 mice.