Table 1.
The network attributes and corresponding P-values for the 24 sub-networks constructed from RNAi hits.
| RNAi screen [Ref] | #hits | #edges | P-value1 | P-value2 |
| Store-operated Ca2+ entry [25] | 1,122 | 4,281 | 2e-05 | 3e-98 |
| ERK signaling [26] | 982 | 7,050 | 2e-71 | <1e-229 |
| Nuclear import of Smads [27] | 683 | 1,321 | 0.07 | 3e-06 |
| Protein secretion and Golgi organization [28] | 645 | 6,597 | <1e-229 | <1e-229 |
| Hh signaling pathway [29] | 306 | 3,214 | <1e-229 | <1e-229 |
| Bacterial infection [30] | 286 | 2,803 | <1e-229 | <1e-229 |
| Growth and viability [31] | 281 | 1,871 | <1e-229 | <1e-229 |
| Wnt signaling pathway [32] | 167 | 368 | 5e-51 | 1e-92 |
| Light-dependent CRY degradation [33] | 131 | 197 | 1e-28 | 9e-105 |
| Neural outgrowth genes [34] | 128 | 414 | 7e-146 | 3e-145 |
| Chlamydia infection [35] | 126 | 107 | 2e-07 | 2e-17 |
| Regulators of NFAT [36] | 121 | 29 | 0.7 | 0.002 |
| Multipolar divisions [37] | 115 | 62 | 0.005 | 9e-12 |
| Viral replication [38] | 104 | 2,069 | <1e-229 | <1e-229 |
| JAK/STAT signaling [39] | 104 | 85 | 4e-09 | 1e-21 |
| Mycobacterial infection [40] | 76 | 176 | 1e-129 | 8e-117 |
| Transcript-specific mRNA export [41] | 65 | 146 | 6e-141 | 2e-100 |
| Ca(2+) influx [42] | 65 | 137 | 3e-123 | 9e-54 |
| Muscle assembly and maintenance [43] | 39 | 21 | 5e-11 | 5e-08 |
| Caspase activation [44] | 37 | 4 | 0.4 | 0.2 |
| Mitochondrial and Peroxisomal Fission [45] | 22 | 2 | 0.3 | 0.1 |
| Histone pre-mRNA processing [46] | 17 | 4 | 2e-04 | 2e-05 |
| E2F repression [47] | 15 | 7 | 2e-13 | 1e-39 |
| Orai proteins [48] | 15 | 9 | 1e-21 | 1e-30 |
Results are sorted based on the number of hits in descending order. The P-value1 and P-value2 are calculated by two different randomization strategies, i.e., 1) randomizing nodes and 2) randomizing edges (with fixed node degree) (see Methods for details).