Table 2.
Adverse Events in 32 Rectal Cancer Patients After Bevacizumab With Chemoradiation (including 5 patients treated with bevacizumab at 10 mg/kg)
| Adverse Event | Grade |
||
|---|---|---|---|
| 1 | 2 | 3 | |
| GI | |||
| Anorexia | 6 | 1 | 1 |
| Constipation | 8 | 1 | 1 |
| Dehydration | — | 2 | 1 |
| Diarrhea | 12 | 5 | 7 |
| Mucositis | 7 | 8 | 1 |
| Perirectal abscess | — | — | 1 |
| Proctalgia/proctitis | 1 | 5 | — |
| Colitis | — | — | 1 |
| GU | |||
| Frequency/urgency | 13 | 5 | — |
| Hesitancy | 2 | — | — |
| Hypertension | 7 | 1 | 3 |
| Hand foot | 3 | 1 | 1 |
| Infection | 1 | 8 | — |
| Skin, radiation dermatitis | 13 | 5 | 2 |
| Neurologic | 4 | 0 | 1 |
| Wound, separation | — | — | 1 |
NOTE. There were no grade 4 events.
Abbreviation: GU, genitourinary.