Table 1.
HWE test, genotype distribution and allele frequencies of the BDNF genetic polymorphisms for autism (n = 124) and controls (n = 120).
| SNP | Group | HWE | Genotype (frequency %) | p value | Allele (frequency %) | p value | ORa | 95%CIb | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CG | GG | C | G | |||||||
| rs988748 | Autism | 0.175 | 33(0.266) | 69(0.556) | 22(0.177) | 0.228 | 135(0.544) | 113(0.456) | 0.807 | 1.045 | 0.732~1.492 |
| Control | 0.293 | 37(0.308) | 54(0.450) | 29(0.242) | 128(0.533) | 112(0.467) | |||||
| AA | AT | TT | A | T | |||||||
| rs2049046 | Autism | 0.208 | 28(0.226) | 69(0.556) | 27(0.218) | 0.191 | 125(0.504) | 123(0.496) | 0.710 | 0.935 | 0.655~1.334 |
| Control | 0.207 | 36(0.300) | 53(0.442) | 31(0.258) | 125(0.521) | 115(0.479) | |||||
| CC | CT | TT | C | T | |||||||
| C270T | Autism | 0.876 | 96(0.774) | 26(0.210) | 2(0.016) | 0.020 | 218(0.879) | 30(0.121) | 0.005 | 0.382 | 0.191~0.766 |
| Control | 0.564 | 108(0.900) | 12(0.100) | 0(0.000) | 228(0.950) | 12(0.050) | |||||
| AA | AG | GG | A | G | |||||||
| rs6265 | Autism | 0.129 | 22(0.177) | 70(0.565) | 32(0.258) | 0.274 | 114(0.460) | 134(0.540) | 0.734 | 0.940 | 0.658~1.342 |
| Control | 0.481 | 29(0.242) | 56(0.467) | 35(0.292) | 114(0.475) | 126(0.525) | |||||
a:
Odds Ratio.
b:
Confidence Intervals.