. Author manuscript; available in PMC: 2010 Jul 1.

Published in final edited form as: Semin Cell Dev Biol. 2009 Mar 18;20(5):620–630. doi: 10.1016/j.semcdb.2009.03.003

Table 2.

Nucleoporin translocation partners in cancer

Nucleoporin		Partner Genes	Partner function	Diseases	Refs
Tpr		Met	HGF receptor tyrosine kinase	gastric carcinoma	42, 45, 46, 123
Tpr		NTrk1	NGF receptor tyrosine kinase	papillary thyroid carcinoma	124, 125

Nup214		DEK	chromatin binding/remodeling	AML, MDS	96
		SET	chromatin binding/remodeling	AML, AUL, T-ALL	95
		ABL1	receptor tyrosine kinase	T-ALL	120

Nup98	HD	HoxA9, 11, 13	transcription factor	AML, MDS, CML	67, 68, 126, 127
		HoxC11, 13	transcription factor	AML, MDS	128, 129, 132
		HoxD11, 13	transcription factor	AML, MDS, CML	130, 131
		PMX1(PRRX1)	transcription factor	AML, MDS, CML	133
		PMX2(PRRX2)	transcription factor	AML, MDS	134
		HHEX	transcription factor	AML	76

	non-HD	DDX10	RNA helicase	AML, MDS	135
		Top1	type I DNA topoisomerase	AML, t-MDS	136, 137, 138
		Top2B	type II DNA topoisomerase	AML	139
		LEDGF	transcriptional co-factor	AML, CML	142
		NSD1	histone methyltransferase	AML	143
		NSD3	histone methyltransferase	AML	144
		SETBP1	SET binding protein	T-ALL	149
		JARIDIA	RbBP2, histone demethylase	ABL	147
		RAP1GDS1	guanine nucleotide exchange factor	T-ALL	140, 141
		Adducin-3	subunit of actin filament binding complex	AML	145
		ANKRD28	ankyrin domain repeats	AML, MDS	148
		PHF23	a hypothetical PHD finger protein	AML	150
		C6ORF80	unknown	AML, T-ALL	146
		LOC348801	unknown	AML	151
		IQCG	unknown	ABL	89

AML: acute myleoid leukemia; MDS: myelodysplastic syndrome; CML: chronic myleoid leukemia; T-ALL: T-cell acute lymphoblastic leukemia; ABL: acute biphenotypic leukemia; t-MDS: therapy-related myelodysplastic syndrome; AUL: acute undifferentiated leukemia; NGF: nerve growth factor