Table 2.
Bins achieving nominally significant evidence for linkage (ALL studies)
| Pos | Bin | cM | Mb | PSR | POR |
|---|---|---|---|---|---|
| 1 | 5.6* | 148.9-178.7 | 141.8-167.7 | 0.00459 | 0.43156 |
| 2 | 2.5* | 117.5-146.9 | 103.3-134.0 | 0.00755 | 0.22798 |
| 3 | 1.6* | 143.1-171.7 | 114.6-162.1 | 0.00814 | 0.06639 |
| 4 | 2.8 | 205.7-235.1 | 206.3-228.3 | 0.00916 | 0.01970 |
| 5 | 2.6* | 146.9-176.3 | 134.0-169.9 | 0.02395 | 0.14269 |
| 6 | 1.4 | 85.8-114.5 | 57.3-84.6 | 0.02692 | 0.08449 |
| 7 | 5.7 | 178.7-208.5 | 167.7-180.4 | 0.02760 | 0.03430 |
| 8 | 8.2* | 28.1-56.2 | 15.7-32.7 | 0.03086 | 0.02070 |
| 9 | 10.6 | 145.9-175.0 | 123.1-135.1 | 0.03487 | 0.01350 |
| 10 | 3.4 | 95.9-127.9 | 71.6-120.2 | 0.04047 | 0.01140 |
Shown are the bins with nominally significant evidence for linkage (PSR <0.05), for ALL studies (30cM bins, weighted analysis), ordered by their position (1 = best) according to weighted analysis PSR (summed rank P-value). POR : ordered rank P-value. Bold PSR values achieved an empirical threshold for suggestive evidence for linkage (PSR < 0.0077). No single bin achieved an empirical genome-wide significant threshold (0.00037).
Empirically (see text), 10 or more bins with nominal PSR < 0.046 was observed in 5% of simulated replicates of this dataset in the absence of linkage. Therefore, it is likely that at least some of the bins listed here contain loci linked to SCZ. Asterisks indicate which regions were consistent with our previous GSMA4 of 20 schizophrenia scans (i.e., bins that overlap with those in the previous analysis that met aggregate significance criteria—that analysis used the Marshfield rather than the Rutgers map, so bin boundaries were not identical). See Figure 2 for further details.