Fig. 2.
Mammalian cell-culture model systems for nuclear migration. (A) NIH-3T3 cells polarize towards a wound edge prior to migration. In response to the addition of a growth factor, the nucleus (blue) migrates away from the wound edge in conjunction with actin flow (yellow arrows), whereas the centrosomes (red) and microtubules (green) remain stationary in the center of the cell. (B) Migrating neuronal precursors in culture. The centrosome (red) migrates forwards at a constant rate into a swelling. The microtubules (green) begin to pull on the nucleus (blue) and the nucleus jumps forwards in large steps with the assistance of actin-myosin contraction (yellow bars) behind the nucleus.