Table I. TREM and TREM-like Receptors in Disease.
TREM message, TREM protein, and sTREM levels are elevated in many inflammatory diseases in both mouse and human. Where indicated, the biological fluids/tissues in which TREM was measured are shown in parentheses. Abbreviations used: ND, Not Determined; BAL, Bronchoalveolar Lavage Fluid; CSF, Cerebrospinal Fluid; COPD, Chronic Obstructive Pulmonary Disease; CAP, Community Acquired Pneumonia; VAP, Ventilator-Associated Pneumonia; IBD, Inflammatory Bowel Disease; NSCLC, Non-small Cell Lung Cancer; TAM, Tumor-Associated Macrophages; CF, Cystic Fibrosis; NHD, Nasu-Hakola Disease; MS, Multiple Sclerosis; OIND, Other Inflammatory Neurological Disease; EAE, Experimental Autoimmune Encephalomyelitis.
Disease |
TREM message |
TREM protein |
sTREM | Species | References |
---|---|---|---|---|---|
TREM-1 | |||||
COPD | ND | ND | Increased (Serum) |
Human | [39] |
CAP | ND | Increased (BAL) |
Increased (Serum,BAL) |
Human | [40-42] |
VAP | ND | ND | Increased (BAL) |
Human | [41,43] |
Pulmonary Aspiration Syndrome |
ND | ND | Increased (BAL) |
Human | [44] |
Exudative Pleural Effusions |
ND | Increased | Increased (Pleural) |
Human | [45,46] |
Acute Pancreatitis |
Increased | ND | Increased (Serum) |
Human | [47,48] |
Peptic Ulcer Disease |
ND | ND | Increased (Gastric) |
Human | [49] |
IBD | Increased (intestinal mucosa) |
Increased (lamina propria) |
Increased (Serum) |
Human | [7,50,51] |
Increased (colon) |
Increased (colon) |
ND | Mouse | [7] | |
Sepsis | Increased | Increased | Increased (Plasma) |
Human | [2,4,52-55] |
Increased | Increased | Increased (Plasma, Serum, Peritoneal) |
Mouse | [3-5] | |
Gout | Increased (Pouch) |
Increased (Pouch) |
Increased (Pouch) |
Mouse | [56] |
NSCLC | ND | Increased (TAM) |
Increased (Pleural) |
Human | [57] |
CF | ND | Decreased (Monocytes) |
No Change (Serum) |
Human | [58] |
TREM-2 | |||||
NHD | Decreased | Decreased | Decreased | Human | [59] |
MS/ OIND |
ND | Decreased (CSF) |
Increased (CSF) |
Human | [13] |
EAE | Increased (spinal cord, brain) |
Increased (spinal cord) |
ND | Mouse | [11] |
TLT-1 | |||||
Sepsis | ND | ND | Increased (plasma) |
Human | Washington V et al., unpublished |
ND | No Change | Increased (plasma) |
Mouse | Washington V et al., unpublished |