Skip to main content
. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Curr Opin Immunol. 2009 Feb 21;21(1):38–46. doi: 10.1016/j.coi.2009.01.009

Table I. TREM and TREM-like Receptors in Disease.

TREM message, TREM protein, and sTREM levels are elevated in many inflammatory diseases in both mouse and human. Where indicated, the biological fluids/tissues in which TREM was measured are shown in parentheses. Abbreviations used: ND, Not Determined; BAL, Bronchoalveolar Lavage Fluid; CSF, Cerebrospinal Fluid; COPD, Chronic Obstructive Pulmonary Disease; CAP, Community Acquired Pneumonia; VAP, Ventilator-Associated Pneumonia; IBD, Inflammatory Bowel Disease; NSCLC, Non-small Cell Lung Cancer; TAM, Tumor-Associated Macrophages; CF, Cystic Fibrosis; NHD, Nasu-Hakola Disease; MS, Multiple Sclerosis; OIND, Other Inflammatory Neurological Disease; EAE, Experimental Autoimmune Encephalomyelitis.

Disease TREM
message
TREM
protein
sTREM Species References
TREM-1
COPD ND ND Increased
(Serum)
Human [39]
CAP ND Increased
(BAL)
Increased
(Serum,BAL)
Human [40-42]
VAP ND ND Increased
(BAL)
Human [41,43]
Pulmonary
Aspiration
Syndrome
ND ND Increased
(BAL)
Human [44]
Exudative
Pleural
Effusions
ND Increased Increased
(Pleural)
Human [45,46]
Acute
Pancreatitis
Increased ND Increased
(Serum)
Human [47,48]
Peptic Ulcer
Disease
ND ND Increased
(Gastric)
Human [49]
IBD Increased
(intestinal
mucosa)
Increased
(lamina
propria)
Increased
(Serum)
Human [7,50,51]
Increased
(colon)
Increased
(colon)
ND Mouse [7]
Sepsis Increased Increased Increased
(Plasma)
Human [2,4,52-55]
Increased Increased Increased
(Plasma,
Serum,
Peritoneal)
Mouse [3-5]
Gout Increased
(Pouch)
Increased
(Pouch)
Increased
(Pouch)
Mouse [56]
NSCLC ND Increased
(TAM)
Increased
(Pleural)
Human [57]
CF ND Decreased
(Monocytes)
No Change
(Serum)
Human [58]
TREM-2
NHD Decreased Decreased Decreased Human [59]
MS/
OIND
ND Decreased
(CSF)
Increased
(CSF)
Human [13]
EAE Increased
(spinal cord,
brain)
Increased
(spinal cord)
ND Mouse [11]
TLT-1
Sepsis ND ND Increased
(plasma)
Human Washington
V et al.,
unpublished
ND No Change Increased
(plasma)
Mouse Washington
V et al.,
unpublished