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. 2009 Jul 28;5:291. doi: 10.1038/msb.2009.46

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Copyright © 2009, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.

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Modules correspond to various aspects of the proteome. Comparison of module membership to the organelle proteome and synaptic proteome. (A) Table depicting modules with nominally significant (P<0.05) enrichment in specific components of either the organelle or synaptic proteome. Three modules have significant overlap with the organelle proteome after strict Bonferroni correction (P<0.004), including the brown (#3), blue (#2), and turquoise (#12) modules. The brown (#3) module overlaps significantly with multiple organelles that are involved in protein trafficking, such as the golgi (P=7.7e−4), recycling endosomes (P=7.4e−11), and the plasma membrane (P=3.0e−5). (B) Barplot showing the comparisons between module membership and the mitochondrial or synaptic proteomes. The y-axis represents the observed to expected ratio of enrichment of either mitochondrial or synaptic proteins (see key) within each module. The asterisk denotes significant enrichment within the module after Bonferroni correction (P<0.004). Mitochondrial proteins are 3.4 (P=6.4e−9) and 2.4 fold (P=5.6e−5) enriched in the blue (#2) and turquoise (#12) modules, respectively. However, the synaptic proteins are only significantly enriched over expected values in the turquoise module (P=2.4e−7).