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. Author manuscript; available in PMC: 2009 Aug 20.
Published in final edited form as: Biochemistry. 2008 Mar 7;47(13):4028–4038. doi: 10.1021/bi701892f

Table 2.

Rate Equations Describing the Reaction Pathways Shown in Figure 1Ba

ν1 = k1[MET][ATP]; k1 = 0.01 ν−1 = k−1[MET–ATP]; k−1 = 0.34
ν2 = k2[MET][Tyr]; k2 = 0.001 ν−2 = k−2[MET–Tyr]; k−2 = 0.3
ν3 = k3[MET–ATP][Tyr]; k3 = 0.001 ν−3 = k−3[MET–ATP–Tyr]; k−3 = 0.18
ν4 = k4[MET–Tyr][ATP]; k4 = 0.01 ν−4 = k−4[MET–ATP–Tyr]; k−4 = 0.29
ν5 = k5[pMET][ATP]; k5 = 0.1 ν−5 = k−5[pMET–ATP]; k−5 = 1.7
ν6 = k6[pMET][Tyr]; k6 = 0.00032 ν−6 = k−6[pMET–Tyr]; k−6 = 0.045
ν7 = k7[pMET–ATP][Tyr]; k7 = 0.0015 ν−7 = k−7[pMET–ATP–Tyr]; k−7 = 0.10
ν8 = k8[pMET–Tyr][ATP]; k8 = 0.1 ν−8 = k−8[pMET–ATP–Tyr]; k−8 = 1.43
ν9 = k9[MET2][ATP]; k9 = 0.01 ν−9 = k−9[MET2–ATP]; k−9 = 0.114
ν10 = k10[MET2][Tyr]; k10 = 0.001 ν−10 = k−10[MET2–Tyr]; k−10 = 0.024
ν11 = k11[MET2–ATP][Tyr]; k11 = 0.001 ν−11 = k−11[MET2–ATP–Tyr]; k−11 = 0.018
ν12 = k12[MET2–Tyr][ATP]; k12 = 0.01 ν−12 = k−12[MET2–ATP–Tyr]; k−12 = 0.166
ν13 = k13[pMET2][ATP]; k13 = 0.1 ν−13 = k−13[pMET2–ATP]; k−13 = 0.57
ν14 = k14[pMET2][Tyr]; k14 = 0.001 ν−14 = k−14[pMET2–Tyr]; k−14 = 0.013
ν15 = k15[pMET2–ATP][Tyr]; k15 = 0.001 ν−15 = k−15[pMET2–ATP–Tyr]; k−15 = 0.016
ν16 = k16[pMET2–Tyr][ATP]; k16 = 0.1 ν−16 = k−16[pMET2–ATP–Tyr]; k−16 = 0.87
ν17 = k17[MET–ATP]; k17 = 0.0008 ν−23 = k−23[MET2]; k−23 = 0.01
ν18 = k18[MET2–ATP]; k18 = 0.24 ν−24 = k−24[pMET2]; k−24 = 0.01
ν19 = k19[MET–ATP–Tyr]; k19 = 0.0008
ν20 = k20 [pMET–ATP–Tyr]; k20 = 0.008
ν21 = k21 [MET2–ATP–Tyr]; k21 = 0.0024
ν22 = k22[pMET2–ATP–Tyr]; k22 = 0.024
ν23 = k23[MET][GF]; k23 = 10
ν24 = k24[pMET][GF]; k24 = 10
ν25 = (V25[pMET2])/(K25 + [pMET2]); V25 = 0.045, K25 = 0.01
ν26 = (V26[pMET])/(K26 + [pMET]); V26 = 0.45, K26 = 0.01
ν27 = (V27[pTyr])/(K27 + [pTyr]); V27 = 0.001, K27 = 0.1
a

All rate constants (k) are given in s−1 (first-order) and in μM−1 s−1 (second-order). All catalytic efficiencies (V) are given in μM s−1, and Michaelis–Menten constants (K, reactions 25−27) are in μM. Constants were obtained as described in Experimental Procedures. For reactions 23, −23, 24, and −24, only one example is given, although the dimerization could occur between any two matching species.