Table 2.
Neural activations during social exclusion vs. inclusion that correlated with increases in IL-6 levels from baseline to two hours post-injection for: A) all females in the endotoxin group and B) all males in the endotoxin group (p < .001, 10-voxel extent threshold). R(ΔDep) refers to the correlation between the parameter estimates from the listed neural activations and self-reported increases in depressed mood. * p < .05; S p < .10.
| Region | BA | MNI Coordinate | T | k | R (ΔDep) | |
|---|---|---|---|---|---|---|
| A) Female endotoxin participants | ||||||
| Positive correlations with IL-6 increases | ||||||
| Paralimbic | ||||||
| Left Anterior Insula | -22 32 4 | 6.06 | 17 | .58A | ||
| Right Anterior Insula | 42 22 -2 | 5.70 | 19 | .69* | ||
| Dorsal Anterior Cingulate Cortex (ACC) | 32 | -8 22 46 | 5.82 | 17 | .72* | |
| Temporal Lobe | ||||||
| Right fusiform gyrus | 37 | 44 -40 -12 | 8.57 | 30 | .55 | |
| Negative correlation with IL-6 increases | ||||||
| Right Somatosensory cortex | 1/2/3 | 64 -16 44 | 6.07 | 11 | -.41 | |
| B) Male endotoxin participants | ||||||
| Positive correlations with IL-6 increases | ||||||
| Paralimbic | ||||||
| Right Anterior Insula | 36 18 -12 | 7.75 | 60 | .03 | ||
| Left Anterior Insula | -20 28 -6 | 7.64 | 21 | -.21 | ||
| Right Posterior Insula | 46 -16 12 | 12.02 | 62 | -.25 | ||
| Left Posterior Insula | -36 -12 12 | 6.39 | 34 | -.12 | ||
| Dorsal/Rostral ACC | 32 | 12 34 24 | 6.79 | 23 | -.09 | |
| Frontal Lobe | ||||||
| Left Ventrolateral Prefrontal Cortex | 44 | -60 4 34 | 9.87 | 12 | -.09 | |
| Right Ventrolateral Prefrontal Cortex | 47 | 46 20 -12 | 7.20 | 14 | .00 | |
| Dorsomedial Prefrontal Cortex | 8 | 18 56 40 | 6.26 | 19 | -.24 | |
| Right Dorsal Premotor Cortex | 6 | 54 4 42 | 7.09 | 19 | -.09 | |
| Supplementary Motor Area | 6 | 10 -18 72 | 5.14 | 10 | -.07 | |
| Parietal Lobe | ||||||
| Left Somatosensory Cortex | 1/2/3 | -40 -16 32 | 8.39 | 27 | -.02 | |
| Temporal Lobe | ||||||
| Posterior Superior Temporal Sulcus | 22 | -58 -42 18 | 11.85 | 46 | -.31 | |
| Left Middle Temporal Gyrus | 21 | -56 -4 -22 | 7.84 | 38 | -.08 | |
| Right Inferior Temporal Gyrus | 20 | 56 -20 -24 | 5.97 | 19 | -.15 | |
| Occipital Lobe | ||||||
| Occipital Cortex | 18 | -40 -80 0 | 8.51 | 50 | -.35 | |
| Cerebellum | ||||||
| Cerebellum | -10 -48 -20 | 10.91 | 100 | -.23 | ||
| Cerebellum | 14 -42 -22 | 8.16 | 128 | -.03 | ||
| Cerebellum | 22 -72 -44 | 6.15 | 11 | .18 | ||
| Cerebellum | -8 -54 -38 | 6.07 | 20 | .02 | ||
| Cerebellum | 22 -58 -40 | 5.94 | 61 | -.22 | ||