Table 3.
Location of the voxel showing the most significant grey matter loss on VBM in each of the group comparisons
Comparison | Region | MNI coordinates | Z score | Cluster size | P value | ||
---|---|---|---|---|---|---|---|
x | y | z | |||||
PCA versus C | Right lateral temporoparietal | 49 | −61 | 42 | >8 | 389623 | <0.000 |
AD versus C | Left medial temporal | −28 | −10 | −18 | >8 | 231019 | <0.000 |
PCA versus AD | Right lateral occipital/temporal | 39 | −85 | −6 | 5.22 | 1041 | <0.000 |
AD versus PCA | Left medial temporal | −26 | −9 | −20 | 5.47 | 2397 | <0.000 |
Voxel coordinates are in millimeters after transformation into standard Montreal Neurologic Institute (MNI) stereotactic space. Results have been corrected for multiple comparisons (p<0.05). PCA = Posterior Cortical Atrophy; AD = Alzheimer's disease; C = control; PCA versus AD = voxel showing greater atrophy in the PCA group than the AD group; AD versus PCA = voxel showing greater atrophy in the AD group than the PCA group.