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. Author manuscript; available in PMC: 2009 Aug 31.
Published in final edited form as: Biochem J. 2008 Jun 1;412(2):179–190. doi: 10.1042/BJ20080281

Figure 3. Direct phosphorylation sites on TSC1 and TSC2.

Figure 3

(A) Phosphorylation of TSC1 at specific residues by different protein kinases. Among these, only the Thr417 site is conserved between human and Drosophila TSC1. For the alignment, the phosphorylation site is indicated in yellow, identical residues in green, strongly similar residues in blue and semi-conserved residues in grey. (B) Same as above, but for TSC2. Among these sites, only the aligned sites are conserved between human and Drosophila TSC2. It should be noted that the AMPK/GSK3 sites in Drosophila (Ser1107/Ser1103) are not found in the same region of the primary sequence as in human TSC2.