Skip to main content
. Author manuscript; available in PMC: 2009 Aug 31.
Published in final edited form as: Biochem J. 2008 Jun 1;412(2):179–190. doi: 10.1042/BJ20080281

Figure 4. Signal integration by the TSC1–TSC2 complex.

Figure 4

The TSC1–TSC2 complex monitors growth conditions through multiple signalling pathways, which either inhibit or activate the complex to affect mTORC1 activity. See the text for details. Further abbreviations: Dvl, dishevelled; Frz, frizzled; MEK, MAPK/ERK kinase; TNFR, tumour-necrosis-factor receptor; VHL, von Hippel–Lindau tumour suppressor; VPS34, vacuolar protein sorting 34.