Table 1.
Vigilance State Parameters Recorded from Orexin/Ataxin-3 Transgenic (Atx), Orexin Knockout (KO) and their Wild-Type Littermate Control (WT) Mice
| Variate | Subjective Day |
Subjective Night |
||||||
|---|---|---|---|---|---|---|---|---|
| WTAtx | Atx | WTKO | KO | WTAtx | Atx | WTKO | KO | |
| Wake | ||||||||
| Total time (min) | 242.4 ± 14.1 | 262.5 ± 8.7 | 302.1 ± 10.6 | 261.0 ± 9.0 | 438.7 ± 11.3 | 433.1 ± 9.8 | 421.4 ± 16.7 | 417.2 ± 14.3 |
| Mean duration (sec) | 109 ± 9 | 98 ± 3 | 152 ± 9 | 93 ± 6** | 248 ± 16 | 175 ± 10** | 252 ± 25 | 143 ± 12** |
| Number of bouts | 134 ± 4 | 160 ± 5** | 121 ± 5 | 170 ± 6** | 108 ± 5 | 150 ± 7** | 104 ± 6 | 178 ± 10** |
| NREM sleep | ||||||||
| Total time (min) | 429.0 ± 13.1 | 404.7 ± 9.5 | 372.7 ± 9.1 | 401.4 ± 8.8* | 263.5 ± 10.1 | 235.4 ± 7.6* | 275.9 ± 14.2 | 245.5 ± 13.9 |
| Mean duration (sec) | 183 ± 5 | 149 ± 7** | 180 ± 7 | 133 ± 5** | 144 ± 8 | 100 ± 3** | 158 ± 8 | 95 ± 3** |
| Number of bouts | 141 ± 4 | 164 ± 5** | 125 ± 5 | 181 ± 9** | 111 ± 6 | 141 ± 7** | 106 ± 7 | 157 ± 14** |
| REM sleep | ||||||||
| Total time (min) | 48.6 ± 2.8 | 48.2 ± 2.3 | 45.2 ± 2.4 | 49.7 ± 3.7 | 17.8 ± 2.9 | 33.8 ± 3.0** | 22.7 ± 2.7 | 23.8 ± 3.7 |
| Mean duration (sec) | 59 ± 3 | 53 ± 2 | 54 ± 4 | 36 ± 2** | 40 ± 4 | 49 ± 3 | 56 ± 5 | 43 ± 4 |
| Number of bouts | 50 ± 3 | 55 ± 4 | 51 ± 4 | 80 ± 4** | 26 ± 3 | 42 ± 4** | 24 ± 3 | 35 ± 7 |
| Cataplexy | ||||||||
| Total time (min) | 0 | 4.6 ± 1.0 | 0 | 8.0 ± 2.3 | 0 | 17.7 ± 2.5 | 0 | 33.3 ± 5.0 |
| Mean duration (sec) | - | 68 ± 4 | - | 80 ± 14 | - | 67 ± 6 | - | 78 ± 5 |
| Number of bouts | 0 | 4 ± 1 | 0 | 7 ± 2 | 0 | 17 ± 3 | 0 | 26 ± 4 |
| Tb (°C) | 36.3 ± 0.3 | 35.9 ± 0.1 | 36.0 ± 0.0 | 36.0 ± 0.0 | 37.5 ± 0.2 | 37.2 ± 0.0 | 37.0 ± 0.1 | 37.5 ± 0.0** |
Total time spent in each state, mean duration, number of bouts and Tb over the subjective day (rest) and night (active) periods. Results shown as mean ± SEM. Significant differences (repeated measures ANOVA) between Atx or KO and their WT littermates are indicated with asterisks (*P < 0.05; **P < 0.01).