Table 1. Results from COS Cell and Neuron Co-Culture Screen of Expression Libraries.
Size Range | # cDNAs Screened* | Positives† | Extracellular Domains | Conserved C-terminus |
---|---|---|---|---|
1-2 kb | 22,000 | none | ||
2-3 kb | 52,050 | NGL-3/LRRC4B PB243 PB270 |
LRR, Ig | -ETQI |
3-4 kb | 22,250 | LRRTM1 PC151 |
LRR | -ECEV |
4-5 kb | 26,750 | neuroligin-2 (3X) | AchE | -TTRV |
Clones were screened in pools of ∼200-250 clones each, in 521 pools.
PB/Cxxx are positive pools that contain novel synaptogenic proteins.