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. Author manuscript; available in PMC: 2010 Aug 1.

Published in final edited form as: Aging Cell. 2009 May 22;8(4):439–448. doi: 10.1111/j.1474-9726.2009.00489.x

Table 1.

Summary of tested correlations in both cohorts.

		All (N=170)				Exploratory (N=80)				Validation (N=90)^***
Response(Y)	Covariate(X)	N^†	R²	Correlation^‡	p-value	N^†	R²	Correlation^‡	p-value	N^†	R²	Correlation^‡	p-value
Log₂[p16^INK4a]	Age	170	0.40	0.63	<.0001	80	0.37	0.61	<.0001	90	0.46	0.68	<.0001
	Pack-yrs	128	0.15	0.38	<.0001	44	0.20	0.45	0.0023	84	0.13	0.36	0.0008
	Extimeswk^*	109	0.18	-0.42	<.0001	32	0.22	-0.47	0.0061	77	0.14	-0.38	0.0007
	Exminse^*	105	0.14	-0.38	<.0001	28	0.30	-0.55	0.0024	77	0.10	-0.31	0.0054
	Exminmo^*	104	0.19	-0.44	<.0001	28	0.28	-0.53	0.0037	76	0.14	-0.38	0.0007
	Serum IL-6^**	145	N/A	N/A	N/A	69	0.08	0.27	0.02	76	0.11	0.33	0.003
	BMI	120	0.01	0.09	0.32	31	0.00	0.04	0.85
	Log₂[ARF]	167	0.18	0.43	<.0001	77	0.40	0.63	<.0001	90	0.30	0.55	<.0001
	Log₂[Exon2/3]	165	0.17	0.41	<.0001	75	0.33	0.57	<.0001	90	0.32	0.57	<.0001
	Log₂[p15^INK4b]	167	0.25	0.50	<.0001	77	0.26	0.51	<.0001	90	0.34	0.59	<.0001
	Log₂[ANRIL]	167	0.31	0.56	<.0001	77	0.32	0.56	<.0001	90	0.38	0.62	<.0001
Log₂[ARF]	Age	167	0.00	0.03	0.67	77	0.01	0.08	0.47
Log₂[Exon2/3]	Age	165	0.00	0.06	0.46	75	0.01	0.08	0.47
Log₂[p15^INK4b]	Age	167	0.01	0.09	0.22	77	0.00	-0.01	0.93
Log₂[ANRIL]	Age	167	0.01	0.11	0.15	77	0.01	0.09	0.45

^*

Extimeswk=exercise times/week; exminse=exercise minutes/session; exminmo=exercise minutes/month

^**

Data were not combined due to batch effect caused by different ELISA measurement experiments.

^***

Only significant correlations in exploratory cohort were tested to confirm.

^†

For some variables, observations used in the analysis are less than total due to missing values

^‡

Pearson Correlation