Table 4.
Associations Between Body Mass Index and Age of Onset of Pancreatic Cancera
| Age of Pancreatic Cancer Onset, y |
||||||
|---|---|---|---|---|---|---|
| Age Period | No. of Patientsb | Median (IQR)c | Mean (SD) | P Valued | Mean Difference (95% Cl)e | P Valued |
| 14-19 y | ||||||
| Normal weight |
579 |
63 (55 to 70) |
62.4 (10.1) |
|
|
|
| Overweight |
120 |
60 (54 to 66) |
59.7 (9.9) |
.004 |
–2.57 (–4.63 to –0.53) |
.01 |
| Obese |
20 |
56 (49 to 66) |
57.3 (13.3) |
.18 |
–5.37 (–9.88 to –0.86) |
.02 |
| 20-29 y | ||||||
| Normal weight |
511 |
63 (55 to 70) |
62.5 (10.4) |
|
|
|
| Overweight |
222 |
62 (54 to 67) |
60.9 (9.4) |
.006 |
–1.56 (–3.23 to 0.11) |
.07 |
| Obese |
49 |
59 (51 to 65) |
56.9 (10.7) |
<.001 |
–5.74 (–8.83 to –2.84) |
<.001 |
| 30-39 y | ||||||
| Normal weight |
417 |
64 (57 to 70) |
63.2 (10.0) |
|
|
|
| Overweight |
300 |
61 (54 to 68) |
61.3 (9.8) |
.01 |
–2.18 (–3.72 to –0.64) |
.006 |
| Obese |
96 |
59 (50 to 65) |
57.6 (9.9) |
<.001 |
–6.02 (–8.27 to –3.79) |
<.001 |
| 40-49 y | ||||||
| Normal weight |
310 |
65 (58 to 71) |
64.4 (9.3) |
|
|
|
| Overweight |
329 |
62 (55 to 68) |
62.2 (9.1) |
.004 |
–2.73 (–4.23 to –1.23) |
<.001 |
| Obese |
157 |
60 (53 to 66) |
60.1 (9.1) |
<.001 |
–5.03 (–6.88 to –3.20) |
<.001 |
| 50-59 y | ||||||
| Normal weight |
184 |
68 (61 to 73) |
67.2 (8.0) |
|
|
|
| Overweight |
313 |
65 (60 to 70) |
65.2 (7.4) |
.008 |
–2.26 (–3.68 to –0.83) |
.002 |
| Obese | 177 | 62 (58 to 68) | 63.3 (7.0) | <.001 | –4.25 (–5.88 to –2.60) | <.001 |
Abbreviations: CI, confidence interval; IQR, interquartile range.
a
Body mass index was calculated as weight in kilograms divided by height in meters squared.
b
The numbers do not add up to totals because individuals with a body mass index of less than 18.5 were not included in the analyses.
c
The IQR is the 25th and 75th percentile.
d
Calculated by linear regression.
e
Estimated by linear regression with age as a dependent variable and body mass index (<25 vs ≥25 or <25 vs ≥30) as an independent variable with adjustment for sex and diabetes status.