Table 2.
Absolute binding of [125I]-iodosulpride in the striatum and midbrain regions of chronic olanzapine- and control-treated rats
Treatment |
||
---|---|---|
Brain regions | Olanzapine (n = 12) | Saline (n = 12) |
NAcc shell | 15.00 ± 0.58 | 13.65 ± 0.87 |
NAcc core | 15.90 ± 0.74 | 14.10 ± 0.66 |
VTA (r) | 5.08 ± 0.26 | 4.87 ± 0.46 |
VTA (c) | 7.66 ± 0.24 | 7.04 ± 0.26 |
DLS | 30.77 ± 1.56* | 25.67 ± 1.26 |
SNpc | 7.56 ± 0.35 | 7.72 ± 0.36 |
Binding is expressed in femtomoles per milligram of tissue equivalent ± SE. NAcc shell, nucleus accumbens shell region; NAcc core, nucleus accumbens core region; VTA (r), ventral tegmental area, rostral expanse; VTA (c), ventral tegmental, caudal expanse; DLS, dorsolateral striatum; SNpc, substania nigra pars compacta.
p < 0.001 significantly different from saline group.