Table 3. Association of SNPs with clinical features related to glucose metabolism in the control subjects.
| Traits | Gene | SNP | AA | Aa | aa | P | Empirical P |
| Fasting glucose (mmol/l) | SLC30A8 | rs13266634 | 5.02±0.02 | 4.99±0.02 | 4.93±0.03 | 0.0118 | 0.1698 |
| 2-h glucose (mmol/l) | TSPAN8-LGR5 | rs7961581 | 5.42±0.04 | 5.48±0.05 | 5.75±0.14 | 0.0404 | 0.3546 |
| Fasting insulin (pmol/l) | TSPAN8-LGR5 | rs7961581 | 45.31±0.98 | 52.31±1.79 | 47.80±4.16 | 0.0054 | 0.0759 |
| 2-h insulin (pmol/l) | CDKN2A-CDKN2B | rs10811161 | 241.69±8.74 | 257.93±7.21 | 284.54±14.22 | 0.0257 | 0.2927 |
| 2-h insulin (pmol/l) | JAZF1 | rs864754 | 268.96±7.11 | 248.23±8.35 | 225.81±15.18 | 0.0110 | 0.1489 |
| 2-h insulin (pmol/l) | TSPAN8-LGR5 | rs7961581 | 247.86±6.16 | 268.68±8.80 | 323.46±53.78 | 0.0171 | 0.2088 |
| 2-h insulin (pmol/l) | THADA | rs7578597 | 258.90±5.05 | 165.79±39.03 | / | 0.0005 | 0.0090 |
| HOMA-IR | TSPAN8-LGR5 | rs7961581 | 1.66±0.04 | 1.93±0.07 | 1.75±0.16 | 0.0039 | 0.0609 |
Only SNPs showed nominal significant association to clinical features are shown in the table. AA represents the homozygotes of major allele. Aa represents the heterozygotes. aa represents the homozygotes of minor allele. Empirical P values were calculated through 1,000 permutations within each trait.